PRURITUS

This study tests a medicine called difelikefalin in teenagers aged 12 to 17 who are on hemodialysis and have moderate to severe itching. The goal is to see if the drug is safe and how much gets into the blood. About 18 teens will receive the medicine up to 4 times a week for 12 w…

This study tests if dupilumab can reduce severe itching in adults with chronic pruritus of unknown origin (CPUO) — a condition where people itch for months without a clear cause. About 284 adults aged 18 to 90 will receive either dupilumab or a placebo for 24 weeks, alongside sta…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can ease chronic symptoms like pain, itch, anxiety, and sleep problems in adult burn survivors. About 34 participants will try both VR-enhanced…

This pilot study tests whether daily neck traction can reduce the need for gabapentin or pregabalin in people with neuropathic itch on the scalp, arms, or upper back. Twelve adults will use a home neck traction device for 12 weeks while their medication dose is adjusted based on …

This study aims to collect blood, skin swabs, skin biopsies, and questionnaire data from 175 adults with chronic itch that has no known skin cause (pruritus sine materia). Researchers hope to better describe the condition and uncover clues about what drives it. Participants will …

This study observes 50 adults with drug-induced liver injury to track how common and how long itching lasts. Researchers will compare them to patients with other liver conditions. The goal is to gather data needed for a future clinical trial to treat this distressing symptom.