Study seeks optimal ephedrine dose for Infants' low blood pressure during surgery

NCT ID NCT02384876

Completed Symptom relief Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested different doses of the drug ephedrine to find the most effective one for treating low blood pressure that occurs during surgery in newborns and infants up to 6 months old. The trial involved 120 infants who developed low blood pressure while under anesthesia. Researchers compared several higher doses against a standard low dose to see which worked best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ephedrine
What this could lead to: If successful, this could establish a safer, more effective dose of ephedrine for treating low blood pressure during surgery in very young infants.
What could go wrong: This is a small, early-phase study (Phase 2) with only 120 participants, so results may not apply to all infants. The study is also completed, so no new data is being collected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFANT, NEWBORN INTRAOPERATIVE ARTERIAL HYPOTENSION

Contacts and locations

Locations

Hospices Civils de Lyon

Lyon, France
Hôpital Nord

Saint-Etienne, 42055, France
Hôpital d'Estaing

Clermont-Ferrand, 63003, France

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