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Numbing cream may ease pain of IUD insertion and biopsies

NCT ID NCT05970354

Symptom relief Sponsor: CAMC Health System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This trial tests whether EMLA cream, a numbing cream with lidocaine and prilocaine, reduces pain during IUD insertion, hysteroscopy, or endometrial biopsy. Participants receive either the cream or a placebo before the procedure and rate their pain on a scale three times. Researchers compare the two groups to see if the cream makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
EMLA cream, a numbing cream containing lidocaine and prilocaine
What this could lead to
If it works, this could give women a simple, drug-free option to reduce pain during common gynecological procedures.
What could go wrong
The trial is small and early, so results may not apply to everyone. The cream may not reduce pain enough to matter, and some people may have skin reactions or allergies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

31 people

The number who actually took part.

Started

Sep 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient will undergo one of the following procedures: intra-uterine device insertion, hysteroscopy, or endometrial biopsies Exclusion Criteria: * Known hypersensitivity to amide anesthetics * Pre-existing methemoglobinemia

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain

Contacts and locations

Locations

  • Charleston Area Medical Center Institute for Academic Medicine

    Charleston, West Virginia, 25302, United States

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