New hope for PBC patients: daily pill aims to protect the liver

NCT ID NCT06730061

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 22 times

Summary

This study tests a daily pill called elafibranor in 18 Japanese adults with primary biliary cholangitis (PBC), a chronic liver disease. The goal is to see if the drug can lower two key markers of liver damage (ALP and bilirubin) over a year, with long-term follow-up. Participants must have had an inadequate response or intolerance to standard treatment (UDCA).

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Contacts and locations

Locations

  • Chugoku Rosai Hospital

    Hiroshima, Japan

  • Fukushima Medical University Hospital

    Fukushima, Japan

  • Hamamatsu University Hospital

    Shizuoka, Japan

  • Juntendo University Hospital

    Tokyo, Japan

  • Kagawa University Hospital

    Kagawa, Japan

  • Kagoshima University Hospital

    Kagoshima, Japan

  • Nagaoka Red Cross Hospital

    Niigata, Japan

  • Nara Medical University Hospital

    Nara, Japan

  • National Hospital Organization Nagasaki Medical Center

    Nagasaki, Japan

  • National Hospital Organization Osaka National Hospital

    Osaka, Japan

  • Niigata University Medical & Dental Hospital

    Niigata, Japan

  • Nippon Medical School - Chiba Hokusoh Hospital

    Chiba, Japan

  • Shinshu University Hospital

    Nagano, Japan

  • Teikyo University Hospital

    Tokyo, Japan

  • Teine Keijinkai Hospital

    Hokkaido, Japan

  • Tokyo Metropolitan Komagome Hospital

    Tokyo, Japan

Conditions

Explore the condition pages connected to this study.