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New drug DYNE-101 aims to ease muscle stiffness in rare disease

NCT ID NCT05481879

Recruiting now Disease control Sponsor: Dyne Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new medicine, DYNE-101, in 116 adults with myotonic dystrophy type 1 (DM1), a condition that causes muscle weakness and stiffness. The main goals are to check if the drug is safe and if it can reduce muscle stiffness and improve muscle function. Participants receive the drug or a placebo by IV over several months, with long-term follow-up.

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Conditions

The condition(s) this trial relates to.

myotonic dystrophy myotonic dystrophy type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOTONIC DYSTROPHY TYPE 1 (DM1)

Contacts and locations

Locations

  • CHU de Nantes

    RECRUITING

    Nantes, 44093, France

  • Centro Clinico Nemo

    RECRUITING

    Milan, 20162, Italy

  • Charité - Universitätsmedizin Berlin

    RECRUITING

    Berlin, 10117, Germany

  • Fondazione Policlinico Universitario A Gemelli-Rome

    RECRUITING

    Rome, 00168, Italy

  • Indiana University School of Medicine

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Institut de Myologie

    RECRUITING

    Paris, 75013, France

  • John Walton Muscular Dystrophy Research Centre

    RECRUITING

    Newcastle upon Tyne, United Kingdom

  • Ludwig Maximilians University, Munich - Friedrich Baur Institut

    RECRUITING

    Munich, 80336, Germany

  • NZCR Auckland

    RECRUITING

    Auckland, 1023, New Zealand

  • Neurology Rare Disease Center

    RECRUITING

    Denton, Texas, 76208, United States

    Contact Email: •••••@•••••

  • Radboud Medical Center

    RECRUITING

    Nijmegen, Netherlands

    Contact Email: •••••@•••••

  • Salford Royal Hospital

    RECRUITING

    Salford, M6 8HD, United Kingdom

  • St. Vincent's Hospital

    RECRUITING

    Fitzroy, Victoria, 3065, Australia

  • Stanford University

    RECRUITING

    Stanford, California, 94305, United States

  • University College London Hospitals

    RECRUITING

    London, NW1 2BU, United Kingdom

  • University of Florida College of Medicine

    RECRUITING

    Gainesville, Florida, 32610, United States

  • University of Iowa

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of Rochester Medical Center

    RECRUITING

    Rochester, New York, 14642, United States

  • Virginia Commonwealth University (VCU)

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Washington University in St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

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