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Durian diet: scientists test the 'King of Fruits' on gut health

NCT ID NCT06194084

Knowledge-focused Sponsor: National Cancer Centre, Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at what happens when healthy adults eat 100 to 200 grams of durian every day for two weeks. Researchers measured changes in blood sugar, cholesterol, and gut bacteria. The goal was to understand how this popular fruit affects the body's microbiome and metabolism. The study is complete and involved 45 volunteers from a hospital staff in Singapore.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
durian pulp
What this could lead to
If the results show clear patterns, this could help design future studies on how specific foods affect gut health and metabolism.
What could go wrong
This is a small, completed study with only 45 healthy volunteers. It does not test any treatment or disease outcome, so findings may not apply to broader populations or health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Feb 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male and/or female subjects between the ages of 21 and 60 years, inclusive 2. Willing and able to provide written informed consent 3. Must be in generally good health with clinically insignificant screening results (Fasting plasma glucose level \& Lipid profile), as determined by the Investigator 4. Agrees to consume durian for 2 weeks 5. Agrees to maintain a low-fiber diet during the intervention 6. Have not received any antibiotics therapy, consumed prebiotics, probiotics, symbiotic /vitamin supplement, and/or TCM for at least 1 month before the start of the study 7. Have not received any medical treatment that would impact on intestinal microbiota at least 6 months before the start of the study or during the study 8. Recent COVID-19 vaccination received or infection with COVID-19 at least 2 months ago Exclusion Criteria: 1. Known or suspected sensitivity/allergy to durian 2. Multiple food/drug allergies 3. Smoker 4. History or presence of current metabolic conditions and gastrointestinal diseases 5. Diagnosed with Inflammatory Bowel Disease (IBD) or significant liver enzyme abnormality 6. Presence of current haemorrhoids or piles causing rectal bleeding when passing stool 7. Pregnant, breastfeeding or intending to conceive during study period

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diet, food and nutrition

Contacts and locations

Locations

  • National Cancer Centre, Singapore

    Singapore, 168583, Singapore

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