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Blood markers may expose hidden dangers of Ultra-Processed foods

NCT ID NCT07717970

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study looks at how different types of ultra-processed foods affect small molecules in the blood. Healthy adults will eat three different highly processed diets and one unprocessed diet, each for two weeks. Researchers will compare blood samples to find markers that could help identify which processed foods are most linked to type 2 diabetes risk. The goal is to develop a blood test that guides healthier food choices.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
controlled diets: non-UPF control, starchy/refined grain UPF diet, and meat/fish/bread UPF diet
What this could lead to
If successful, this could help identify which types of ultra-processed foods are most harmful, leading to better dietary guidelines for preventing type 2 diabetes.
What could go wrong
This is a small, early-stage study with only 40 participants, so results may not apply to everyone. It identifies markers but does not directly test whether changing diet prevents diabetes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults, ages 20 to 65 years. * BMI 18.5 to 39.9 kg/m2. * No known food allergies, intolerances, or sensitivities (e.g., gluten, dairy, monosodium-glutamate). * Not following a restrictive diet for health, religious, or other reasons (e.g., vegetarian, vegan). * Willingness to participate and give informed consent. * Willingness to consume dietary intervention foods and beverages. Exclusion Criteria: * BMI \<18.5 or \>39.9 kg/m2. * Pregnant, lactating, or planning on becoming pregnant in the next 6 months. * History of bariatric surgery. * Currently taking medications impacting appetite or body weight. * History of major chronic diseases, including cardiovascular disease, type 1 or 2 diabetes, major gastrointestinal conditions, uncontrolled hypertension (seated blood pressure systolic \>140 mmHg or diastolic \>90 mmHg), history of invasive cancer, current use of immunosuppressants, and other major chronic diseases and conditions affecting participation, adherence, or study endpoints. * Unwilling or unable to comply with all in person scheduled visits, dietary protocols, study protocol, and other study procedures. * Food allergies or aversions to the foods provided in the dietary interventions. * Non-English speaking. * Other members of the same household are already participating in the research study. * Planning on moving out of the Boston area in the next 6 months.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diet, food and nutrition

How to take part

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  2. The official record

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Contacts and locations

Locations

  • Brigham and Women's Hopital Center for Clinical Investigation

    Boston, Massachusetts, 02115, United States

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