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Can a common sedative added to spinal anesthesia keep older minds clear after hip surgery?

NCT ID NCT07810556

Prevention Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Older adults who break a hip and have surgery often develop postoperative delirium, a sudden state of confusion that can slow recovery. Researchers are testing whether adding a small dose of dexmedetomidine to standard spinal anesthesia reduces how often this confusion occurs. In this trial, 130 patients aged 65 and older having hip fracture surgery receive either dexmedetomidine plus bupivacaine or bupivacaine alone. The team checks for delirium twice daily for two days after surgery and tracks pain, side effects, and hospital stay.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine, a sedative drug added to spinal anesthesia
What this could lead to
If it works, this could give anesthesiologists a simple way to lower the risk of confusion after hip fracture surgery in older adults.
What could go wrong
This is a mid-stage trial with 130 participants, so results may not hold in larger or different groups. Dexmedetomidine can lower heart rate and blood pressure, and the spinal injection carries small risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Elderly patients aged 65 years or older. * American Society of Anesthesiologists (ASA) physical status I, II, or III. * Patients scheduled for elective or emergency hip fracture surgeries (e.g., internal fixation, hemiarthroplasty, or total hip arthroplasty). * Eligible for and scheduled to undergo the procedure under spinal anesthesia. * Written informed consent provided by the patient or their legally authorized representative. Exclusion Criteria: * Patient or legal representative refusal to participate in the study or receive spinal anesthesia. * Absolute contraindications to spinal anesthesia (e.g., coagulopathy, bleeding disorders, localized infection at the puncture site, or severe hypovolemia). * Pre-existing cognitive or neurological impairment (diagnosed dementia, baseline Mini-Mental State Examination \[MMSE\] score \< 24, history of recent stroke, severe psychiatric illness, or chronic use of sedatives/antidepressants). * Cardiovascular contraindications (baseline bradycardia with heart rate \< 50 beats/min, advanced second- or third-degree atrioventricular block, or severe baseline hypotension with mean arterial pressure \< 65 mmHg). * Severe end-stage organ failure (severe hepatic or renal impairment). * Severe auditory or visual impairment hindering proper cognitive evaluation, or inability to communicate. * Intraoperative failure of spinal anesthesia requiring conversion to general anesthesia, surgical duration exceeding 2 hours, or massive intraoperative blood loss/hemodynamic instability.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium hip fracture delirium prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hip fractures Postoperative delirium

How to take part

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  1. The official record

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