Could a natural steroid ease depression in HIV patients?
NCT ID NCT05570812
First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 32 times
Summary
This study tests whether a supplement called pregnenolone can help reduce depression in people living with HIV. Researchers will give either pregnenolone or a placebo pill to 120 adults with HIV and depression, while they continue their usual antidepressant medications. Brain scans and mood questionnaires will measure changes in brain chemistry and depressive symptoms over the study period.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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