Could a brain steroid ease depression in HIV patients?
NCT ID NCT05570812
First seen Oct 31, 2025 · Last updated May 27, 2026 · Updated 35 times
Summary
This study tests whether a supplement called pregnenolone can improve depression symptoms in people living with HIV. Participants take either pregnenolone or a placebo pill for a period, while continuing their usual antidepressant medications. Researchers use brain scans and questionnaires to see if the supplement changes brain chemistry and mood. The study involves 120 adults aged 18-85 with well-controlled HIV and significant depressive symptoms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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