New depression drug shows promise in large trial

NCT ID NCT06029426

Completed Symptom relief Sponsor: Neumora Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental oral drug, NMRA-335140, against a placebo in 383 adults with major depressive disorder. Participants took the drug or placebo daily for 6 weeks, and researchers measured changes in depression symptoms using a standard rating scale. The goal was to see if the drug could safely reduce depression better than a sugar pill.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Neumora Investigator Site

Garden Grove, California, 92845, United States
Neumora Investigator Site

Glendale, California, 91206, United States
Neumora Investigator Site

Imperial, California, 92251, United States
Neumora Investigator Site

Lafayette, California, 94549, United States
Neumora Investigator Site

Long Beach, California, 90807, United States
Neumora Investigator Site

Los Angeles, California, 90015, United States
Neumora Investigator Site

Oceanside, California, 92056, United States
Neumora Investigator Site

Orange, California, 92868, United States
Neumora Investigator Site

Riverside, California, 92506, United States
Neumora Investigator Site

San Jose, California, 95124, United States
Neumora Investigator Site

Sherman Oaks, California, 91403, United States
Neumora Investigator Site

Temecula, California, 92591, United States
Neumora Investigator Site

Torrance, California, 90504, United States
Neumora Investigator Site

Colorado Springs, Colorado, 80910, United States
Neumora Investigator Site

Gainesville, Florida, 32607, United States
Neumora Investigator Site

Hallandale, Florida, 33009, United States
Neumora Investigator Site

Jacksonville, Florida, 32256, United States
Neumora Investigator Site

Lauderhill, Florida, 33319, United States
Neumora Investigator Site

Maitland, Florida, 32751, United States
Neumora Investigator Site

Miami, Florida, 33122, United States
Neumora Investigator Site

Miami, Florida, 33125, United States
Neumora Investigator Site

Miami, Florida, 33183, United States
Neumora Investigator Site

Miami Lakes, Florida, 33016, United States
Neumora Investigator Site

Orlando, Florida, 32801, United States
Neumora Investigator Site

Tampa, Florida, 33607, United States
Neumora Investigator Site

Marietta, Georgia, 30060, United States
Neumora Investigator Site

Chicago, Illinois, 60634, United States
Neumora Investigator Site

Evanston, Illinois, 60201, United States
Neumora Investigator Site

Warrenville, Illinois, 60555, United States
Neumora Investigator Site

Boston, Massachusetts, 02116, United States
Neumora Investigator Site

Methuen, Massachusetts, 01844, United States
Neumora Investigator Site

Watertown, Massachusetts, 02472, United States
Neumora Investigator Site

Bloomfield Hills, Michigan, 48302, United States
Neumora Investigator Site

Flowood, Mississippi, 39232, United States
Neumora Investigator Site

Saint Charles, Missouri, 63304, United States
Neumora Investigator Site

Las Vegas, Nevada, 89102, United States
Neumora Investigator Site

Brooklyn, New York, 11224, United States
Neumora Investigator Site

Cedarhurst, New York, 11516, United States
Neumora Investigator Site

New York, New York, 10036, United States
Neumora Investigator Site

Staten Island, New York, 10314, United States
Neumora Investigator Site

Cleveland, Ohio, 44106, United States
Neumora Investigator Site

Columbus, Ohio, 43210, United States
Neumora Investigator Site

Dayton, Ohio, 45417, United States
Neumora Investigator Site

Garfield Heights, Ohio, 44125, United States
Neumora Investigator Site

Allentown, Pennsylvania, 18104, United States
Neumora Investigator Site

Media, Pennsylvania, 19063, United States
Neumora Investigator Site

Plymouth Meeting, Pennsylvania, 19462, United States
Neumora Investigator Site

Memphis, Tennessee, 38119, United States
Neumora Investigator Site

Austin, Texas, 78737, United States
Neumora Investigator Site

Dallas, Texas, 75235, United States
Neumora Investigator Site

Houston, Texas, 77030, United States
Neumora Investigator Site

Houston, Texas, 77090, United States
Neumora Investigator Site

Wichita Falls, Texas, 76309, United States
Neumora Investigator Site

Charlottesville, Virginia, 22903, United States
Neumora Investigator Site

Bellevue, Washington, 98007, United States
Neumora Investigator Site

Everett, Washington, 98201, United States
Neumora Investigator Site

Huntsville, Alabama, 35801, United States
Neumora Investigator Site

Phoenix, Arizona, 85012, United States
Neumora Investigator Site

Bentonville, Arkansas, 72712, United States
Neumora Investigator Site

Little Rock, Arkansas, 72211, United States
Neumora Investigator Site

Rogers, Arkansas, 72758, United States
Neumora Investigator Site

Bellflower, California, 90706, United States
Neumora Investigator Site #1

Sherman Oaks, California, 91403, United States
Neumora Investigator Site-1

Little Rock, Arkansas, 72211, United States

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