Baking soda in numbing shots could ease carpal tunnel surgery pain

NCT ID NCT05328180

Ongoing Symptom relief Sponsor: Kuopio University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether adding sodium bicarbonate (baking soda) to the local anesthetic used during carpal tunnel release surgery reduces the pain of the injection itself. 116 adults with carpal tunnel syndrome will be randomly assigned to receive either buffered or standard anesthetic. The main goal is to see if the buffered solution causes less burning, pressure, and overall pain during the injection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sodium bicarbonate added to local anesthetic (lidocaine and bupivacaine with adrenaline)
What this could lead to: If it works, this could make the numbing injection less painful for people having carpal tunnel surgery.
What could go wrong: This is a small, early-stage trial (116 people) testing a minor change to a standard procedure. Even if it reduces injection pain, the effect may be small or not apply to everyone.

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Conditions

The condition(s) this trial relates to.

carpal tunnel syndrome Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARPAL TUNNEL SYNDROME

Contacts and locations

Locations

Kuopio University hospital, Department of Orthopaedics, Traumatology and Hand Surgery

Kuopio, Northern Savonia, 70029, Finland

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