Can an Anti-Inflammatory pill revive immunotherapy in tough melanoma?
NCT ID NCT04971499
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether adding dapansutrile (an anti-inflammatory pill) to pembrolizumab (an immunotherapy) can help people with advanced melanoma whose cancer no longer responds to PD-1 inhibitors. About 26 adults with unresectable stage III or IV melanoma will take part. The study first finds a safe dose, then checks if the combination shrinks tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- dapansutrile (an oral anti-inflammatory drug) plus pembrolizumab (an immunotherapy)
- What this could lead to
- If it works, this combination could offer a new treatment option for people with advanced melanoma that no longer responds to standard immunotherapy.
- What could go wrong
- This is an early-phase trial with only 26 participants, so results may not apply broadly. The drug combination may cause side effects or fail to shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Duke Cancer Center
Durham, North Carolina, 27710, United States
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Other studies related to the condition(s) this trial covers.
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