Sleep apnea drug trial halted: can danavorexton still help after surgery?

NCT ID NCT05814016

Terminated Symptom relief Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a single dose of danavorexton in 41 people with moderate to severe sleep apnea who were having abdominal surgery. The goal was to see if the drug could help them breathe steadily in the recovery room. The trial was terminated early, so results are incomplete.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: danavorexton
What this could lead to: If it works, this could help people with sleep apnea breathe more easily after surgery, reducing complications.
What could go wrong: This was a small, early-phase trial that was terminated, so results are limited. The drug may not work or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SLEEP APNEA

Contacts and locations

Locations

Brigham and Womens Hospital

Boston, Massachusetts, 02115-6110, United States
Cedars Sinai Medical Hospital

West Hollywood, California, 90048, United States
Cleveland Clinic Florida

Weston, Florida, 33331-3609, United States
Cleveland Clinic Hospital

Cleveland, Ohio, 44195-0001, United States
Fairview Hospital

Cleveland, Ohio, 44111-5612, United States
Helen Keller Hospital

Sheffield, Alabama, 35660-6334, United States
Inspira Health

Mullica Hill, New Jersey, 09061, United States
Mayo Clinic - PPDS - Hospital

Phoenix, Arizona, 85054-4502, United States
Mayo Clinic Jacksonville - PPDS

Jacksonville, Florida, 32224-1865, United States
Medical Research Center - Clinic/Outpatient Facility

Miami, Florida, 33165, United States
NYU Langone

Mineola, New York, 11501-3893, United States
Ohio State University Wexner Medical Center

Columbus, Ohio, 43210-1240, United States
Rush University

Chicago, Illinois, 60622, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794-0001, United States
The Medical College of Wisconsin, Inc.

Milwaukee, Wisconsin, 53226-3522, United States
UCSD

La Jolla, California, 92037-1300, United States
University of Louisville - Hospital

Louisville, Kentucky, 40202-3700, United States
University of Miami - Leonard M. Miller School of Medicine

Miami, Florida, 33136-1005, United States
University of South Florida

Tampa, Florida, 33606-3601, United States

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