New antibiotic coating could shield heart surgery patients from dangerous infections

NCT ID NCT03558984

Terminated Prevention Sponsor: PolyPid Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This trial tests whether D-PLEX, an extended-release form of the antibiotic doxycycline, can prevent sternal wound infections in people at high risk after cardiac surgery. Participants receive D-PLEX along with standard intravenous antibiotics, or standard antibiotics alone. The study tracks infections, hospital stays, and any need for repeat surgery over 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: D-PLEX (extended-release doxycycline)
What this could lead to: If effective, D-PLEX could reduce serious sternal infections after heart surgery, shortening hospital stays and avoiding repeat operations.
What could go wrong: This is an early-stage trial with only 2 participants enrolled, so results may not apply broadly. The treatment may not prevent infections better than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC SURGERY STERNAL INFECTION SURGICAL SITE INFECTION

Contacts and locations

Locations

Mayo Clinic

Rochester, Minnesota, 55902, United States
Memorial Hermann

Huston, Texas, 77024, United States
Soroka Medical Center

Beersheba, Israel

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