New antibiotic coating could shield heart surgery patients from dangerous infections
NCT ID NCT03558984
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This trial tests whether D-PLEX, an extended-release form of the antibiotic doxycycline, can prevent sternal wound infections in people at high risk after cardiac surgery. Participants receive D-PLEX along with standard intravenous antibiotics, or standard antibiotics alone. The study tracks infections, hospital stays, and any need for repeat surgery over 90 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
D-PLEX (extended-release doxycycline)
What this could lead to
If effective, D-PLEX could reduce serious sternal infections after heart surgery, shortening hospital stays and avoiding repeat operations.
What could go wrong
This is an early-stage trial with only 2 participants enrolled, so results may not apply broadly. The treatment may not prevent infections better than standard care.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic
Rochester, Minnesota, 55902, United States
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Memorial Hermann
Huston, Texas, 77024, United States
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Soroka Medical Center
Beersheba, Israel