Creatine pills tested for menopause brain fog and fatigue

NCT ID NCT06660004

Completed Symptom relief Sponsor: University of Novi Sad, Faculty of Sport and Physical Education Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking creatine supplements for 8 weeks could improve fatigue, thinking skills, and brain chemistry in perimenopausal and menopausal women. 36 women took either creatine HCl, creatine ethyl ester, or a placebo. Researchers measured fatigue levels, exercise endurance, brain creatine levels, and cognitive interference. The trial is complete, but results are not yet reported.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: creatine (creatine HCl and creatine ethyl ester)
What this could lead to: If it works, this could point toward a simple dietary supplement to help with fatigue and brain fog during menopause.
What could go wrong: This is a small, early-stage trial with only 36 participants. Results may not apply to all women, and supplements can cause digestive upset or other mild side effects.

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Conditions

The condition(s) this trial relates to.

Fatigue

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENOPAUSAL PERIMENOPAUSE

Contacts and locations

Locations

FSPE Applied BIoenergetcis Lab

Novi Sad, Vojvodina, 21000, Serbia

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