Filler Face-Off: which injectable smooths smile lines best?
NCT ID NCT06351293
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compared two hyaluronic acid fillers, Defyne and RHA3, for treating nasolabial folds (smile lines) in 15 adults aged 22 to 65. Each participant received one filler on each side of their face, with an optional touch-up after 4 weeks. Researchers used ultrasound and 3D imaging to measure filler placement and volume changes over 12 months.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Aesthetic Clinique
Santa Rosa Beach, Florida, 32459, United States
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