Filler Face-Off: which wrinkle treatment wins for smile lines?
NCT ID NCT06351293
First seen Jan 19, 2026 · Last updated May 01, 2026 · Updated 15 times
Summary
This study tested two hyaluronic acid fillers (Defyne and RHA3) on smile lines in 15 adults. Each person received one filler on each side of the face to compare results. The goal was to see which filler works better and lasts longer over 12 months.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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The Aesthetic Clinique
Santa Rosa Beach, Florida, 32459, United States
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