Can two radiation therapies team up to fight liver cancer?
NCT ID NCT04518748
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This trial is testing whether combining two types of radiation therapy can safely treat liver cancer that cannot be removed with surgery. The approach uses Y-90 microspheres delivered directly to the liver, followed by targeted external radiation (SBRT). The study also uses PET-CT imaging to help plan the radiation more precisely. The main goal is to check the safety of this combination and see how it affects liver function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Yttrium-90 (Y-90) microspheres given via selective internal radiation therapy (SIRT), followed by stereotactic body radiation therapy (SBRT)
- What this could lead to
- If safe and effective, this combination could offer a new way to treat liver cancer that cannot be removed surgically, potentially improving local control of tumors.
- What could go wrong
- This is an early-phase trial focused on safety, so the combination may not prove more effective than standard treatments. There is a risk of liver damage or other side effects from the radiation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEPATOCELLULAR CARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a simple scan and blood test outsmart liver cancer?
- Could a vaccine help fight Hard-to-Treat cancers?
- Could a tailored diet before surgery boost liver cancer recovery?
- Can a new PET tracer light up hidden cancers?
- A new test could reveal how radiation affects the liver
- Can an immunotherapy drug keep liver cancer at bay after surgery?