Can collagen injections quiet persistent back pain?

NCT ID NCT07675304

Recruiting now Symptom relief Sponsor: National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether injecting collagen, lidocaine (a numbing agent), or a mix of both into the lower back can reduce pain and improve movement in people with chronic low back pain. Participants receive five weekly sessions of tiny injections into the muscles and soft tissues around the spine. The goal is to see if this approach, called mesotherapy, can ease pain and help people engage more easily in physical therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Type I tropocollagen and/or lidocaine (lignocaine) injections
What this could lead to: If effective, this approach could offer a minimally invasive option to ease chronic low back pain and support physical therapy.
What could go wrong: This is a very early-phase study with only 90 participants, so results may not apply broadly. Pain relief may be modest or temporary, and there is a risk of allergic reactions or injection-site issues.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LOW BACK PAIN (NON-SPECIFIC, UNCOMPLICATED)

Contacts and locations

Locations

National Institute of Geriatrics, Rheumatology and Rehabilitation
RECRUITING

Warsaw, Poland

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