Can a cold snare match heat for polyp removal?

NCT ID NCT07764224

Not yet recruiting Disease control Sponsor: Nanfang Hospital, Southern Medical University Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial compares two endoscopic techniques for removing flat, non-cancerous colorectal polyps that are 10-20 mm in size. One method uses a cold snare (no heat), while the other uses a hot snare with electrocautery. The goal is to see if the cold approach is just as effective at completely removing the polyps and whether it offers safety benefits. Adults aged 18-75 with such polyps may participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cold snare endoscopic mucosal resection (CS-EMR) versus hot snare endoscopic mucosal resection (HS-EMR)
What this could lead to: If cold snare removal works as well as the hot method, it could offer a safer, simpler way to remove certain colorectal polyps, potentially reducing procedure-related risks.
What could go wrong: This is a non-inferiority trial, so it aims to show cold snare is not worse than hot snare, but it may not be better. There are risks like bleeding or incomplete removal, and results may not apply to all polyp types.

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Conditions

The condition(s) this trial relates to.

colorectal adenoma polyp of large intestine

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL POLYPS ENDOSCOPIC MUCOSAL RESECTION

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