Could a common ED drug boost fertility in PCOS?

NCT ID NCT07769476

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This trial asks whether adding sildenafil citrate to the standard fertility drug clomiphene citrate can improve ovulation and pregnancy rates in women with polycystic ovary syndrome (PCOS) who have been trying to conceive for over two years. About 98 women aged 18–45 will be randomly assigned to receive either clomiphene alone or clomiphene plus sildenafil for 12 weeks. Researchers will track ovulation, pregnancy, and uterine lining thickness to see if the combination offers an advantage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
clomiphene citrate plus sildenafil citrate
What this could lead to
If adding sildenafil works, it could offer a simple, affordable way to boost ovulation and pregnancy chances for women with PCOS who struggle to conceive.
What could go wrong
This is a small, early-stage comparison, and the added benefit of sildenafil is uncertain. Side effects or lack of effect are possible, and results may not apply to all women with PCOS.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Nishtar Medical University

    Multan, Punjab Province, 60000, Pakistan

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