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Can routine ICU vital signs reveal broken body clocks?

NCT ID NCT07811492

Knowledge-focused Sponsor: Charite University, Berlin, Germany Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers are examining how the body's natural day-and-night rhythms behave in people treated in the intensive care unit. The study uses routine data already collected during and after ICU stays, including heart rate, temperature, blood pressure, blood sugar, and insulin. The team wants to learn whether these measurements show daily patterns and whether patients can be grouped by their rhythm profiles. They also explore whether factors like illness severity, sedation, organ support, or medications are linked to changes in these rhythms, and whether conditions such as delirium, muscle weakness, or post-intensive care syndrome are associated with disturbed physiological rhythms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the approach works, doctors could one day use routine ICU data to spot disrupted body clocks and adjust lighting or care to help patients recover.
What could go wrong
This is a retrospective study of existing records, so it can show patterns but not prove cause and effect. The findings may not apply to other hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 25,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Charite University, Berlin, Germany

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Primary Retrospective Cohort: * Admitted to and treated in a participating Intensive Care Unit (ICU) between 2017 and 2024 * Minimum ICU length of stay of 3 days (≥ 72 hours) * Age ≥ 18 years at the time of ICU admission * All genders (male, female, diverse) Cohorts from previous studies: * Prior enrollment in one of the designated parent study protocols * Availability of supplementary biological or metabolic data (e.g., clock gene expression, melatonin levels) suitable for exploratory association analyses Exclusion Criteria: * None

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Conditions

The condition(s) this trial relates to.

circadian rhythm sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Circadian rhythm

Contacts and locations

Locations

  • Institute of Medical Informatics, Charite University, Berlin

    Berlin, 10117, Germany

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