New drug CIN-103 tested for IBS-D, but trial halted early

NCT ID NCT06153420

Terminated Symptom relief Sponsor: CinPhloro Pharma, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tested whether CIN-103, taken twice daily, could ease symptoms of irritable bowel syndrome with diarrhea (IBS-D) in adults. The study planned to enroll 421 participants and compare two doses of CIN-103 against a placebo over 12 weeks. However, the trial was terminated, so its findings are incomplete.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CIN-103
What this could lead to: If it works, this could point toward a new treatment option for people with IBS-D to reduce abdominal pain and improve stool consistency.
What could go wrong: This trial was terminated early, so results are limited. It is still in Phase 2, meaning it is not yet proven safe or effective for widespread use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRRITABLE BOWEL SYNDROME WITH DIARRHEA

Contacts and locations

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Locations

Advanced Gastroenterology

Union City, Tennessee, 38261, United States
Advanced Research Institute

Ogden, Utah, 84405, United States
Advanced Research Institute - Reno

Reno, Nevada, 89511, United States
Albuquerque Clinical Trials, Inc

Albuquerque, New Mexico, 87102, United States
Allied Digestive Health Clinical Research Organization

Somers Point, New Jersey, 08244, United States
Allied Digestive Health-Jersey Shore Gastroenterology - Point Commons

Somers Point, New Jersey, 08244, United States
American Family Research Group

Cape Coral, Florida, 33909, United States
Applied Research Center of Arkansas

Little Rock, Arkansas, 72212, United States
Atrium Health - Center for Gastroenterology and Hepatology MMP

Charlotte, North Carolina, 28204, United States
Care and Cure Clinic

Houston, Texas, 77090, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Clinical Research Associates, LLC

Huntsville, Alabama, 35801, United States
DelRicht Research

Mandeville, Louisiana, 70471, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
DelRicht Research of Bethesda Clinical Trials

Rockville, Maryland, 20852, United States
DelRicht Research of Charleston Clinical Trials

Charleston, South Carolina, 29407, United States
Delta Research Partners, LLC

West Monroe, Louisiana, 71291, United States
Digestive Disease Specialists

Las Vegas, Nevada, 89128, United States
Digestive Health Specialists - Dothan

Dothan, Alabama, 36305, United States
Elite Clinical Studies LLC

Phoenix, Arizona, 85018, United States
GI Alliance - Sun City

Sun City, Arizona, 85351, United States
GI Alliance - Washington Gastroenterology

Tacoma, Washington, 98405, United States
GLRI - McAllen Research

Pharr, Texas, 78577, United States
Galen Medical Group - Downtown Gastroenterology Location

Chattanooga, Tennessee, 37404, United States
Gastro Care Institute- lancaster

Lancaster, California, 93534, United States
Gastroenterology Research of San Antonio

San Antonio, Texas, 78229, United States
Great Lakes Gastroenterology Research LLC

Mentor, Ohio, 44060, United States
IMA Clinical Research

Mount Airy, North Carolina, 27030, United States
IMA Clinical Research PC and Affiliates- New York, NY

New York, New York, 10128, United States
Innovation Medical Research Center

Palmetto Bay, Florida, 33157, United States
International Research Associates LLC

Miami, Florida, 33183, United States
Las Vegas Medical Research

Las Vegas, Nevada, 89113, United States
Medical Associates Research Group

San Diego, California, 92123, United States
NY Scientific

New York, New York, 11235, United States
Northshore Gastroenterology Research, LLC

Westlake, Ohio, 44145, United States
Options Health Research LLC

Tulsa, Oklahoma, 74104, United States
Palmetto Clinical Research

Summerville, South Carolina, 29485, United States
Paragon Rx Clinical, Inc. - Garden Grove

Garden Grove, California, 92840, United States
Peters Medical Research

High Point, North Carolina, 27262, United States
Quality Clinical Research, Inc

Omaha, Nebraska, 68114, United States
Quality Research Inc

San Antonio, Texas, 78209, United States
Remington Davis, Inc.

Columbus, Ohio, 43215, United States
Southwest Gastroenterology

Oak Lawn, Illinois, 60453, United States
St. Charles Clinical Research

Weldon Spring, Missouri, 63304, United States
Susquehanna Research Group, LLC

Harrisburg, Pennsylvania, 17110, United States
Tandem Clinical Research GI LLC

Marrero, Louisiana, 70072, United States
Tandem Clinical Research GI LLC

Metairie, Louisiana, 70006, United States
The Clinical Trials Network LLC

Houston, Texas, 77074, United States
The University of Texas Health Science Center at Houston

Bellaire, Texas, 77401, United States
Tri-Cities Gastroenterology

Kingsport, Tennessee, 37663, United States
USA and International Research Inc.

Doral, Florida, 33126, United States
Velocity Clinical Research,, Savannah

Savannah, Georgia, 31406, United States
Westchester Putnam Gastro

Carmel Hamlet, New York, 10512, United States

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