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Could the time of day you get immunotherapy boost its power against melanoma?

NCT ID NCT07574047

Not yet recruiting Disease control Sponsor: Swiss Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study looks at whether giving immunotherapy infusions in the morning improves outcomes for people with advanced melanoma. Researchers will compare morning versus afternoon/evening dosing in 108 participants. The goal is to see if aligning treatment with the body's natural immune rhythms can help patients live longer without their cancer growing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Immune checkpoint inhibitors (nivolumab, pembrolizumab, ipilimumab)
What this could lead to
If timing matters, this could lead to a simple change in when immunotherapy is given, potentially improving survival without new drugs.
What could go wrong
This is a small, early-phase trial (108 people) testing a timing hypothesis, not a new treatment. Results may not confirm benefit or apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MELANOMA MELANOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Centre Hospitalier Universitaire Vaudois (CHUV)

    Lausanne, 1011, Switzerland

  • Ente Ospedaliero Cantonale (EOC)

    Bellinzona, 6500, Switzerland

  • HFR Fribourg

    Fribourg, Canton of Fribourg, 1708, Switzerland

  • HOCH Health Ostschweiz - Kantonsspital St. Gallen

    Sankt Gallen, 9007, Switzerland

  • Hôpitaux Universitaires de Genève HUG

    Geneva, 1211, Switzerland

  • Inselspital, Bern

    Bern, 3010, Switzerland

  • Spital Thurgau (Kantonsspital Münserlingen und Frauenfeld)

    Münsterlingen, 8596, Switzerland

  • Universitätsspital Zürich USZ

    Zurich, 8091, Switzerland

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