Could a new pill curb binge eating? phase 2 trial underway

NCT ID NCT05113953

Completed Symptom relief Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This Phase 2 trial tested two doses of centanafadine sustained-release tablets against a placebo in 147 adults with moderate to severe binge eating disorder. The main goal was to see if the drug could reduce the number of binge eating days per week. Researchers also looked at changes in overall illness severity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

centanafadine sustained-release tablets

What this could lead to

If it works, this could point toward a new medication to help reduce binge eating episodes in people with binge eating disorder.

What could go wrong

This is an early Phase 2 trial with only 147 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

binge eating disorder Binge-Eating Disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BINGE EATING DISORDER

Contacts and locations

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Locations

ActivMed Practices and Research - Portsmouth

Portsmouth, New Hampshire, 03801, United States
Boston Clinical Trials

Boston, Massachusetts, 02131, United States
Center for Emotional Fitness

Cherry Hill, New Jersey, 08002, United States
Clinical Neuroscience Solutions - Jacksonville

Jacksonville, Florida, 32256, United States
Clinical Neuroscience Solutions, Inc.

Memphis, Tennessee, 38119, United States
Collaborative Neuroscience Research, LLC

Garden Grove, California, 92845, United States
Collective Medical Research

Prairie Village, Kansas, 66208, United States
Craig and Frances Linder Center of Hope

Mason, Ohio, 45040, United States
FutureSearch Trials - Dallas

Dallas, Texas, 75231, United States
Manhattan Behavioral Medicine

New York, New York, 10036, United States
Medical Research Network, LLC

New York, New York, 10128, United States
Miami Dade Medical Research Institute

Miami, Florida, 33176, United States
Midwest Clinical Research Center

Dayton, Ohio, 45417, United States
Mountain View Clinical Research, LLC

Denver, Colorado, 80209, United States
NoesisPharma, LLC

Phoenix, Arizona, 85016, United States
Pacific Clinical Research Management Group LLC

Upland, California, 91786, United States
Pharmacology Research Institute - San Fernando Valley

Encino, California, 91316, United States
Princeton Medical Institute

Princeton, New Jersey, 08540, United States
Psych Atlanta, PC

Marietta, Georgia, 30060, United States
Psychiatric Associates

Overland Park, Kansas, 66211, United States
Psychiatry + Psychotherapy Partners Austin

Austin, Texas, 78737, United States
Richmond Behavioral Associates

Staten Island, New York, 10312, United States
Southern California Research LLC

Beverly Hills, California, 90210, United States
St. Charles Psychiatric Associates & Midwest Research Group

Weldon Spring, Missouri, 63304, United States
iResearch Atlanta

Decatur, Georgia, 30030, United States