New CAR T-Cell therapy takes aim at tough T-Cell cancers

NCT ID NCT06316856

Recruiting now Disease control Sponsor: Beijing GoBroad Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment called CD5 CAR T-cells for people with T-cell cancers (like certain leukemias) that have returned or not responded to standard care. The treatment uses a patient's own immune cells or cells from a donor, which are modified in a lab to recognize and attack cancer cells. The trial has two phases: first to find a safe dose, then to see how well it shrinks tumors. About 54 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CD5 CAR T-cells (immune cells engineered to target cancer)
What this could lead to: If it works, this could offer a new treatment option for people with hard-to-treat T-cell cancers that have not responded to standard therapies.
What could go wrong: This is an early-phase trial with only 54 participants, so results may not apply broadly. CAR T-cell therapy can cause severe side effects like cytokine release syndrome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma T-cell acute lymphoblastic leukemia T-cell and NK-cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA, IN RELAPSE REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA T CELL MALIGNANCIES T-CELL ACUTE LYMPHOCYTIC LEUKEMIA

Contacts and locations

Locations

Beijing GoBroad Hospital
RECRUITING

Beijing, Beijing Municipality, 102206, China
Shanghai Liquan Hospital
RECRUITING

Shanghai, Shanghai Municipality, 201418, China
The General Hospital of Western Theater Command PLA
NOT_YET_RECRUITING

Chengdu, Sichuan, 610083, China
Zhaxin Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai
RECRUITING

Shanghai, Shanghai Municipality, 200435, China

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