Outpatient cancer treatment breakthrough: modified immune cells fight lymphoma

NCT ID NCT05459571

First seen Nov 01, 2025 · Last updated Apr 14, 2026 · Updated 24 times

Summary

This study tested a personalized cancer treatment called CAR-T cell therapy for people with aggressive lymphoma that has returned or resisted previous treatments. Researchers gave patients modified immune cells along with preventive steroids and monitored them in outpatient settings instead of requiring hospital stays. The main goals were to see if this approach was safe, reduced severe side effects, and effectively controlled the cancer.

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Contacts and locations

Locations

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • City of Hope (City of Hope National Medical Center, City of Hope Medical Center)

    Duarte, California, 91010, United States

  • Colorado Blood Cancer Institute

    Denver, Colorado, 80218, United States

  • Henry-Joyce Cancer Clinic

    Nashville, Tennessee, 37232, United States

  • Huntsman Cancer Institute, University of Utah

    Salt Lake City, Utah, 84112, United States

  • Intermountain Healthcare

    Murray, Utah, 84107, United States

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Methodist Healthcare System of San Antonio

    San Antonio, Texas, 78229, United States

  • Oncology Hematology Care Clinical Trials, LLC

    Cincinnati, Ohio, 45242, United States

  • Prisma Health - Upstate

    Greenville, South Carolina, 29615, United States

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203, United States

  • UCLA

    Los Angeles, California, 90025, United States

  • University of Maryland Greenebaum Comprehensive Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Virginia Health System

    Charlottesville, Virginia, 22908, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23219, United States

  • Virginia Oncology Associates

    Norfolk, Virginia, 23502, United States

Conditions

Explore the condition pages connected to this study.