Outpatient CAR T-Cell therapy shows promise for tough lymphoma

NCT ID NCT05459571

Completed Disease control Sponsor: Kite, A Gilead Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a cancer treatment called axicabtagene ciloleucel (a CAR T-cell therapy) given with preventive steroids to 35 adults with large B-cell lymphoma that had returned or not responded to prior treatments. The goal was to see if giving the therapy in an outpatient setting (without staying overnight in the hospital) is safe and manageable. Researchers tracked side effects like cytokine release syndrome and nerve problems, as well as how many people needed hospitalization.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RELAPSED OR REFRACTORY LARGE B-CELL LYMPHOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Recurrence relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED OR REFRACTORY LARGE B-CELL LYMPHOMA

Contacts and locations

Locations

Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)

Duarte, California, 91010, United States
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Henry-Joyce Cancer Clinic

Nashville, Tennessee, 37232, United States
Huntsman Cancer Institute, University of Utah

Salt Lake City, Utah, 84112, United States
Intermountain Healthcare

Murray, Utah, 84107, United States
John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Methodist Healthcare System of San Antonio

San Antonio, Texas, 78229, United States
Oncology Hematology Care Clinical Trials, LLC

Cincinnati, Ohio, 45242, United States
Prisma Health - Upstate

Greenville, South Carolina, 29615, United States
Tennessee Oncology, PLLC

Nashville, Tennessee, 37203, United States
UCLA

Los Angeles, California, 90025, United States
University of Maryland Greenebaum Comprehensive Cancer Center

Baltimore, Maryland, 21201, United States
University of Virginia Health System

Charlottesville, Virginia, 22908, United States
Virginia Commonwealth University

Richmond, Virginia, 23219, United States
Virginia Oncology Associates

Norfolk, Virginia, 23502, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.