New immune cell therapy takes on tough lymphoma

NCT ID NCT06079164

Ongoing Disease control Sponsor: Kite, A Gilead Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing a new treatment called KITE-197 for people with large B-cell lymphoma that has come back or not responded to other treatments. KITE-197 is made from a patient's own immune cells, which are modified in a lab to better attack cancer cells. The study will first check safety and dosing in a small group, then look at how well the recommended dose works in another group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: KITE-197 (a CAR T-cell therapy made from the patient's own immune cells)
What this could lead to: If it works, this could offer a new treatment option for people with hard-to-treat large B-cell lymphoma.
What could go wrong: This is a very early, small Phase 1 trial, so it may not work or could have serious side effects. The results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

large B-cell lymphoma Recurrence relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED/REFRACTORY LARGE B-CELL LYMPHOMA

Contacts and locations

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Locations

Cross Cancer Institute

Edmonton, T6G 1Z2, Canada
Henry-Joyce Cancer Clinic

Nashville, Tennessee, 37232, United States
Jewish General Hospital

Montreal, H3T 1E2, Canada
QEII Health Sciences Centre

Halifax, B3H 2Y9, Canada
Royal Brisbane and Women's Hospital

South Brisbane, Queensland, 4101, Australia
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia
St. David's South Austin Medical Center

Austin, Texas, 78704, United States
Swedish Cancer Institute

Seattle, Washington, 98104, United States
Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
The Alfred Hospital

Melbourne, Victoria, 3004, Australia
University of Chicago Medical Center

Chicago, Illinois, 60637, United States

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