Engineered immune cells take on tough leukemia in new trial

NCT ID NCT04404660

Ongoing Disease control Sponsor: Autolus Limited Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a treatment called AUTO1, a type of CAR T cell therapy, in 153 adults whose B cell acute lymphoblastic leukemia has returned or not responded to standard treatments. The therapy involves taking a patient's own immune cells, engineering them to recognize and attack cancer cells, and giving them back after chemotherapy. The goal is to see if it is safe and effective at controlling the leukemia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AUTO1 (also called obecabtagene autoleucel or obe-cel), a CAR T cell therapy that targets CD19 on cancer cells
What this could lead to: If successful, this could offer a new treatment option for adults with hard-to-treat B cell acute lymphoblastic leukemia, potentially leading to long-term disease control.
What could go wrong: This is an early-phase (1b/2) trial, so the therapy may not work for everyone. Side effects can be serious, including cytokine release syndrome and neurological issues.

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Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia Burkitt lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED OR REFRACTORY B CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Contacts and locations

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Locations

Baylor Scott & White Research Institute

Dallas, Texas, 75246, United States
Cambridge University Hospitals NHS Foundation Trust

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
City of Hope National Medical Center

Duarte, California, 93534, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute (CBCI)

Denver, Colorado, 80218, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
Fundacio' Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
H Lee Moffitt Cancer Center

Tampa, Florida, 33612, United States
Hospital Universitario La Fé

Valencia, 46026, Spain
Hospital Universitario Virgen del Rocío

Seville, 41013, Spain
King's College Hospital

London, Greater London, SE5 9RS, United Kingdom
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Manchester Royal Infirmary Hospital

Manchester, Greater Manchester, M13 9WL, United Kingdom
Mayo Clinic

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Queen Elizabeth University Hospital

Glasgow, Scotland, G514TF, United Kingdom
TTI-Methodist (Texas Transplant Institute) (SCRI)

San Antonio, Texas, 78229, United States
The Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
TriStar Centennial Medical Center (SCRI)

Nashville, Tennessee, 37203, United States
University College London Hospitals NHS Foundation Trust

London, Greater London, NW1 2PG, United Kingdom
University Hospitals Birmingham NHS Foundation Trust

Birmingham, West Midlands, B15 2GW, United Kingdom
University Hospitals Bristol and Weston NHS Foundation Trust (UHBW)

Bristol, BS2 8ED, United Kingdom
University of California Davis (UC Davis)

Sacramento, California, 95817, United States
University of California San Diego Health (UCSD)

La Jolla, California, 92093, United States
University of California San Francisco (UCSF)

San Francisco, California, 94143, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Kansas

Kansas City, Kansas, 66160, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Miami

Miami, Florida, 33136, United States
University of Nebraska

Omaha, Nebraska, 68105, United States
University of Rochester

Rochester, New York, 14642, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Winship Cancer Institute of Emory University

Atlanta, Georgia, 30322, United States

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