Can a single drug stop blood cancer before it starts?

NCT ID NCT05641831

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 21 times

Summary

This study tests whether the drug canakinumab can prevent blood cancer in people with a condition called CCUS, where blood counts are low and there are genetic changes that raise cancer risk. The drug works by reducing inflammation, which may be a trigger for cancer. About 110 adults with high-risk CCUS will receive either canakinumab or a placebo, and researchers will track how many develop leukemia or related cancers over time.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • UT Southwestern Medical Center at Dallas

    RECRUITING

    Dallas, Texas, 75235, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Miami

    RECRUITING

    Miami, Florida, 33136, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Weill Cornell Medical College

    RECRUITING

    New York, New York, 10021, United States

    Contact Phone: •••-•••-••••

    Contact

Conditions

Explore the condition pages connected to this study.