Could an 8-Week alcohol break lower blood pressure and protect the heart?

NCT ID NCT07783061

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This trial asks whether stopping alcohol for 8 weeks can improve blood pressure and other heart health markers in adults aged 26 to 49 who drink heavily and have high blood pressure. Participants are randomly assigned to either abstain from alcohol or continue their usual drinking habits. Researchers will compare changes in blood pressure, arterial stiffness, and blood vessel function between the two groups to see if a short alcohol break could reduce cardiovascular risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Alcohol abstinence (behavioral intervention)
What this could lead to
If successful, this could support alcohol abstinence as a simple, drug-free way to lower blood pressure and reduce heart disease risk in at-risk drinkers.
What could go wrong
The trial is small and short-term, and results may not apply to all drinkers. Abstinence may be hard to maintain, and blood pressure improvements might not be sustained after the study ends.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 148 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Sep 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

26 to 49 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria * Men and women aged 26 to 49 years * At-risk drinkers who drink over the recommended limits, defined as those with PEth (≥20 ng/dL) or those with a U.S. Alcohol Use Disorders Identification Test (USAUDIT) score ≥8/7 for men/women * Elevated blood pressure or hypertension (systolic blood pressure: 120-160 mmHg and/or diastolic blood pressure 80-100 mmHg) Exclusion criteria * History of CVD or cardiovascular events (e.g., stroke, myocardial infarction) * The presence of myocardial ischemia or arrhythmias with abnormal ECG and blood pressure during a clinically-supervised maximal graded exercise test * Hypertension (systolic \>160 mmHg and diastolic \>100 mmHg) * On more than one anti-hypertensive medication, or on other physician-prescribed medications (but not including oral contraceptives) * Major psychiatric disorders, including autism, ADHD, bipolar disorder, major depression, schizophrenia, and substance use disorders * Alcohol use disorder, PEth ≥400 ng/mL, or USAUDIT score ≥ 25 * Current or history of any tobacco use in the past 6 months (including, but not limited to, cigarettes, e-cigarettes, hookah, Nicorette, snus and chewing tobacco) * Current or history of illicit and recreational drug use (more than 3 times in the past month and more than 15 times in their lifetime) * Diabetes type 1 \& type 2 with fasting blood glucose ≥126 mg/dL * Presence of renal disease with a creatinine \> 1.5 mg/dL * Presence of liver disease with liver enzymes \> 3x the upper limits of normal * Anemia with a hemoglobin \< 8 g/dL * Diagnosis of chronic inflammatory disease such as, but not limited to, cancer * Diagnosis of chronic autoimmune diseases such as, but not limited to lupus, multiple sclerosis, rheumatoid arthritis * Diagnosis of chronic obstructive pulmonary disease, pulmonary fibrosis, pneumonia, lung cancer, and cystic fibrosis * Diagnosis of neurological diseases, including seizure disorders, Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, traumatic brain injury, and peripheral neuropathies * Body mass index \<18.5 or ≥40 kg/m2 * Unstable body weight (\>5% change during the past 6 months) * Obstructive sleep apnea * Night-shift work * Women who are pregnant (or intend to become pregnant while participating in study), breastfeeding, or postmenopausal

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Conditions

The condition(s) this trial relates to.

Alcohol Drinking Drinking Behavior hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Science and Engineering Innovation and Research Building (SEIR), University of Texas at Arlington

    Arlington, Texas, 76010, United States

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