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Can workouts and brain games shield aging brains?

NCT ID NCT04962061

Prevention Sponsor: Louis Bherer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether combining aerobic and resistance exercise with cognitive training can improve thinking skills in sedentary adults aged 60 and older who have cardiovascular risk factors. Participants will do exercise sessions and computer-based brain games over several weeks. Researchers will measure changes in memory, processing speed, and executive function to see if the combined approach helps more than exercise alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A combination of aerobic and resistance exercise plus cognitive training sessions
What this could lead to
If it works, this could point toward a drug-free way to protect memory and thinking in older adults at risk for heart problems.
What could go wrong
The trial is early and the results may not apply to everyone. Some participants might find the training hard to stick with, and benefits could be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

159 people

The number who actually took part.

Started

Sep 2021

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult aged 60 and older, * Normal or corrected vision and normal hearing for their age range, * No cognitive impairment (Mini-Mental State Examination - MMSE ≥ 25), * Inactive (\< 150 min of physical activity per week). Exclusion Criteria: * MMSE ≤ 24 or diagnosis of dementia, * Uncontrolled psychological / psychiatric condition within the past 6 months, * Neurological disease, * Severe exercise intolerance, * Respiratory disease (e.g., asthma, COPD), * Excessive alcohol consumption (\> 15 drinks/week), * Documented cerebral, peripheral or coronary atherosclerotic disease, * Chronic systolic or diastolic heart failure, * Symptomatic aortic stenosis, * Atrial fibrillation, * Automatic implantable defibrillator or permanent pacemaker, * Malignant exertional arrhythmias, * Non-cardiopulmonary limitation to exercise (e.g., arthritis).

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Conditions

The condition(s) this trial relates to.

Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Cardiovascular risk factor

Contacts and locations

Locations

  • Preventive medicine and physical activity centre (centre EPIC), Montreal Heart Institute

    Montreal, Quebec, H1T1N6, Canada

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