Engineered immune cells take on rare Muscle-Weakening disease

NCT ID NCT06359041

Recruiting now Disease control Sponsor: Cabaletta Bio Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This early-stage study tests a new treatment called CABA-201 for people with generalized myasthenia gravis, a condition that causes severe muscle weakness. The therapy uses a patient's own immune cells, modified to target and destroy faulty immune cells that attack the body. The main goal is to check safety and see if it can reduce symptoms, though long-term medication may still be needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

autoimmune disease myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALIZED MYASTHENIA GRAVIS (GMG)

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Baylor College of Medicine Neurology Department
RECRUITING

Houston, Texas, 77030, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Mayo Clinic - Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Swedish Neuroscience Research
RECRUITING

Seattle, Washington, 98122, United States
UC Davis, Department of Neurology
RECRUITING

Sacramento, California, 95817, United States
University of California Irvine
RECRUITING

Orange, California, 92868, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States

Contact Email: •••••@•••••
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Massachusetts Chan Medical School
RECRUITING

Worcester, Massachusetts, 01655, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.