Can zapping your brain while you sleep and meditating make you think clearer and feel better?

NCT ID NCT06267521

Completed Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether gentle electrical brain stimulation during sleep, combined with daily meditation exercises, can improve how flexibly people think and how well they regulate their emotions. 64 healthy adults participated over up to 9 months. The goal was to see if these techniques, alone or together, could positively affect brain networks linked to thinking and mood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transcranial electrical stimulation with temporal interference (TES-TI) and meditation training via the Healthy Minds App
What this could lead to: If successful, this could point toward a non-drug approach to improve mental flexibility and emotional well-being.
What could go wrong: This is an early-phase study with only 64 participants, so results may not apply to the general population. The interventions are experimental and may not produce meaningful changes.

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Conditions

The condition(s) this trial relates to.

Emotional Regulation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE FLEXIBILITY EMOTIONAL REGULATION

Contacts and locations

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Locations

Center for Healthy Minds

Madison, Wisconsin, 53703, United States

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