Brain cancer study halted: new radiation methods tested for recurrent tumors

NCT ID NCT04588246

Terminated Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen May 20, 2026 · Last updated May 20, 2026

Summary

This study looked at two ways to treat cancer that has spread to the brain and returned after initial radiation. One method used focused radiation only on the new tumors, while the other used whole-brain radiation while trying to protect memory areas and adding a medication to reduce side effects. The goal was to see which approach better controlled the cancer and reduced the chance of death from brain-related causes. The study was stopped early because not enough people enrolled, so the results are limited.

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Contacts and locations

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Locations

Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada
California Pacific Medical Center-Pacific Campus

San Francisco, California, 94115, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, 21044, United States
Chelsea Hospital

Chelsea, Michigan, 48118, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States
City of Hope Antelope Valley

Lancaster, California, 93534, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
City of Hope Corona

Corona, California, 92882, United States
City of Hope South Bay

Torrance, California, 90503, United States
City of Hope South Pasadena

South Pasadena, California, 91030, United States
City of Hope Upland

Upland, California, 91786, United States
City of Hope at Irvine Lennar

Irvine, California, 92618, United States
Covenant Medical Center-Lakeside

Lubbock, Texas, 79410, United States
Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, 19713, United States
Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154, United States
Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095, United States
Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, 17901, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, Maryland, 21237, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital West

Pembroke Pines, Florida, 33028, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Pamela Youde Nethersole Eastern Hospital

Chai Wan, Hong Kong
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Riddle Memorial Hospital

Media, Pennsylvania, 19063, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Siteman Cancer Center at Christian Hospital

St Louis, Missouri, 63136, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Sutter Roseville Medical Center

Roseville, California, 95661, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014, United States
UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601, United States
UPMC Memorial

York, Pennsylvania, 17408, United States
UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
Upstate Cancer Center at Verona

Verona, New York, 13478, United States
Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.

ANATOMIC STAGE IV BREAST CANCER AJCC V8 METASTATIC LUNG NON-SMALL CELL CARCINOMA METASTATIC LUNG SMALL CELL CARCINOMA METASTATIC MALIGNANT BREAST NEOPLASM METASTATIC MALIGNANT DIGESTIVE SYSTEM NEOPLASM METASTATIC MALIGNANT NEOPLASM IN THE BRAIN METASTATIC MALIGNANT SOLID NEOPLASM METASTATIC MELANOMA METASTATIC RENAL CELL CARCINOMA RECURRENT BRAIN NEOPLASM STAGE IV LUNG CANCER AJCC V8 STAGE IV RENAL CELL CANCER AJCC V8