Could a blood pressure drug help fight melanoma?
NCT ID NCT01009177
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tested whether adding bosentan, a drug used for blood vessel conditions, to standard chemotherapy (dacarbazine) could slow tumor growth in people with stage IV melanoma. The study enrolled 80 adults with advanced melanoma and compared the combination to chemotherapy alone. The main goal was to see how long patients lived without their cancer getting worse.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Bosentan
What this could lead to
If successful, this could point toward a new combination treatment to slow tumor growth in advanced melanoma.
What could go wrong
This is an early Phase 2 trial with only 80 participants, so results may not be conclusive. Bosentan is already used for other conditions and may not improve outcomes in melanoma.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Barwon Health - The Geelong Hospital
Geelong, VIC 3220, Australia
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Cabrini Hopsital - Oncology Department
Malvern, VIC 2144, Australia
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Mater Adult Hospital
South Brisbane, QLD 4001, Australia
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Mount Medical Centre
Perth, WA, Australia
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New Castle Melanoma Unit
Newcastle, NSW, Australia
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Pacific Private Clinic
Southport, QLD 4215, Australia
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Redcliffe Hospital - Dept Oncology & Palliative Care
Redcliffe, QLD 4020, Australia
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Royal North Shore Hospital
St Leonards, NSW, Australia
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Southern Medical Day Care Centre
Wollongong, NSW, Australia
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Sydney Cancer Centre, Royal Prince Alfred Hospital
Sydney, NSW, Australia
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Sydney Haematology and Oncology Unit
Hornsby, NSW, Australia
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Westmead Hospital - Department of Oncology
Westmead, NSW 2145, Australia