Could a blood pressure drug help fight melanoma?

NCT ID NCT01009177

Completed Disease control Sponsor: Actelion Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tested whether adding bosentan, a drug used for blood vessel conditions, to standard chemotherapy (dacarbazine) could slow tumor growth in people with stage IV melanoma. The study enrolled 80 adults with advanced melanoma and compared the combination to chemotherapy alone. The main goal was to see how long patients lived without their cancer getting worse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bosentan
What this could lead to: If successful, this could point toward a new combination treatment to slow tumor growth in advanced melanoma.
What could go wrong: This is an early Phase 2 trial with only 80 participants, so results may not be conclusive. Bosentan is already used for other conditions and may not improve outcomes in melanoma.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

melanoma metastatic melanoma Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA

Contacts and locations

Locations

Barwon Health - The Geelong Hospital

Geelong, VIC 3220, Australia
Cabrini Hopsital - Oncology Department

Malvern, VIC 2144, Australia
Mater Adult Hospital

South Brisbane, QLD 4001, Australia
Mount Medical Centre

Perth, WA, Australia
New Castle Melanoma Unit

Newcastle, NSW, Australia
Pacific Private Clinic

Southport, QLD 4215, Australia
Redcliffe Hospital - Dept Oncology & Palliative Care

Redcliffe, QLD 4020, Australia
Royal North Shore Hospital

St Leonards, NSW, Australia
Southern Medical Day Care Centre

Wollongong, NSW, Australia
Sydney Cancer Centre, Royal Prince Alfred Hospital

Sydney, NSW, Australia
Sydney Haematology and Oncology Unit

Hornsby, NSW, Australia
Westmead Hospital - Department of Oncology

Westmead, NSW 2145, Australia

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