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Can body weight predict success of knee realignment surgery?

NCT ID NCT06590818

Disease control Sponsor: Egymedicalpedia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This study looks at whether body mass index (BMI) influences the short-term results of high tibial osteotomy (HTO), a surgery that realigns the knee to relieve pain from osteoarthritis with a varus (bow-legged) deformity. Researchers will track 50 patients in Upper Egypt who undergo HTO, measuring blood loss during and after surgery, as well as knee function and pain levels. The goal is to see if heavier patients have different outcomes, which could help guide treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High tibial osteotomy (HTO), a surgical procedure to realign the knee
What this could lead to
If successful, this could help doctors predict which patients with knee osteoarthritis and varus deformity might benefit most from HTO, potentially improving surgical outcomes and patient selection.
What could go wrong
This is a small, early-stage study (50 participants) and results may not apply to broader populations. Surgery carries risks like bleeding, infection, and blood clots, and the effect of BMI on outcomes is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Jul 2024

Finished

Jul 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meet the diagnostic criteria for knee osteoarthritis and only have one knee * No serious underlying medical disease * Conservative treatment is ineffective and there is a willingness for surgery * X-ray shows degeneration limited to the medial joint space (Ahlback grade ≥ grade II) * Knee flexion range of motion \> 90°, varus deformity \< 15°, flexion contracture \< 5°. * Clinical examination shows intact anterior cruciate ligament and collateral ligament, tenderness point is limited to the medial joint space, and the lateral compartment and patellofemoral joint are intact. Exclusion Criteria: * knee osteoarthritis caused by infection, blood-related or autoimmune diseases. * severe obesity (BMI\>35 kg/m 2 ) or morbid obesity (obesity caused by diseases such as hypercortisolism and hypothyroidism, BMI≥30 kg/m 2 ).

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteo arthritis knee Varus knee

Contacts and locations

Locations

  • Al-Azhar University hospitals

    Asyut, Egypt

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