Blood test may predict lung decline in rare disease

NCT ID NCT04844359

Ongoing Knowledge-focused Sponsor: National Jewish Health Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is looking for markers in the blood that can predict whether a person's chronic hypersensitivity pneumonitis will get worse over time. Researchers will follow about 137 patients at 7 U.S. centers for 24 months, tracking lung function, symptoms, and CT scans. The goal is to develop a tool that helps doctors personalize care, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple blood test that helps doctors predict which patients with chronic hypersensitivity pneumonitis will get worse, allowing for earlier and more personalized treatment.
What could go wrong: This is an observational study, not a treatment trial. It is relatively small (137 people) and only looks for patterns in the blood. The findings may not apply to all patients or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypersensitivity pneumonitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERSENSITIVITY PNEUMONITIS

Contacts and locations

Locations

Mayo Clinic

Rochester, Minnesota, 55905, United States
National Jewish Health

Denver, Colorado, 80206, United States
University of Arizona

Tucson, Arizona, 85719, United States
University of California Davis

Sacramento, California, 95817, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Texas Southwestern

Dallas, Texas, 75390, United States
University of Utah

Salt Lake City, Utah, 84108, United States

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