New combo therapy aims to slow lung scarring in hypersensitivity pneumonitis
NCT ID NCT05626387
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 4 trial tests whether adding mycophenolate mofetil (MMF) to standard prednisolone treatment works better than prednisolone alone for fibrotic hypersensitivity pneumonitis, a lung condition where scarring makes breathing hard. About 144 adults with at least 40% predicted lung function will be randomly assigned to one of the two groups. The main goal is to see how fast lung function declines over one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mycophenolate mofetil (MMF) plus prednisolone
What this could lead to
If it works, this could provide a more effective and safer treatment option for people with fibrotic hypersensitivity pneumonitis, potentially slowing lung function decline.
What could go wrong
This is a relatively small, single-center trial. The combination therapy may not prove more effective than prednisolone alone, and immunosuppressants carry risks like infection and bone marrow suppression.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AIIMS, Jodhpur
Jodhpur, India
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AIIMS, New Delhi
New Delhi, India
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AIIMS, Rishikesh
Rishikesh, India
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CMC Vellore
Vellore, India
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Postgraduate Institute of Medical Education and Research
Chandigarh, Chandigarh, 160012, India
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Rajasthan Hospital Jaipur
Jaipur, India
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Safdarjung Hospital Delhi
New Delhi, India
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Sanjay Gandhi Postgraduate Institute
Lucknow, India
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Yashoda Hospitals Hyderabad
Hyderabad, India