New combo therapy aims to slow lung scarring in hypersensitivity pneumonitis

NCT ID NCT05626387

Ongoing Disease control Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 4 trial tests whether adding mycophenolate mofetil (MMF) to standard prednisolone treatment works better than prednisolone alone for fibrotic hypersensitivity pneumonitis, a lung condition where scarring makes breathing hard. About 144 adults with at least 40% predicted lung function will be randomly assigned to one of the two groups. The main goal is to see how fast lung function declines over one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mycophenolate mofetil (MMF) plus prednisolone
What this could lead to: If it works, this could provide a more effective and safer treatment option for people with fibrotic hypersensitivity pneumonitis, potentially slowing lung function decline.
What could go wrong: This is a relatively small, single-center trial. The combination therapy may not prove more effective than prednisolone alone, and immunosuppressants carry risks like infection and bone marrow suppression.

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Conditions

The condition(s) this trial relates to.

fibrotic hypersensitivity pneumonitis hypersensitivity pneumonitis interstitial lung disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERSENSITIVITY PNEUMONITIS

Contacts and locations

Locations

AIIMS, Jodhpur

Jodhpur, India
AIIMS, New Delhi

New Delhi, India
AIIMS, Rishikesh

Rishikesh, India
CMC Vellore

Vellore, India
Postgraduate Institute of Medical Education and Research

Chandigarh, Chandigarh, 160012, India
Rajasthan Hospital Jaipur

Jaipur, India
Safdarjung Hospital Delhi

New Delhi, India
Sanjay Gandhi Postgraduate Institute

Lucknow, India
Yashoda Hospitals Hyderabad

Hyderabad, India

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