New combo therapy shows promise for relapsed leukemia

NCT ID NCT03160079

First seen Nov 10, 2025 · Last updated May 02, 2026 · Updated 23 times

Summary

This early-phase study tested a combination of two drugs, blinatumomab and pembrolizumab, in 16 adults with a type of blood cancer (B-cell acute lymphoblastic leukemia) that had come back or not responded to prior treatment. The goal was to see if adding pembrolizumab to blinatumomab could improve the number of patients who achieve complete remission (no detectable cancer cells). Participants had high levels of cancer cells in their bone marrow at the start.

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Contacts and locations

Locations

  • UC Irvine Health Chao Family Comprehensive Cancer Center

    Orange, California, 92868, United States

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCSF Comprehensive Cancer Center

    San Francisco, California, 94143, United States

  • UCSF Fresno Community Cancer Institute

    Clovis, California, 93611, United States

Conditions

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