New hope for aggressive brain cancer: experimental drug berubicin faces off against standard care

NCT ID NCT04762069

First seen Apr 27, 2026 · Last updated Apr 28, 2026 · Updated 1 time

Summary

This study tests an experimental drug called berubicin in adults whose glioblastoma (a fast-growing brain tumor) has come back after standard treatment. About 252 participants will receive either berubicin or the standard chemotherapy lomustine. The main goal is to see if berubicin helps people live longer. Researchers will also check if the drug shrinks tumors and how safe it is.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Atlantic Healthcare

    Summit, New Jersey, 07901, United States

  • Baptist MD Anderson Cancer Center

    Jacksonville, Florida, 32207, United States

  • Baptist Miami

    Miami, Florida, 33176, United States

  • Baylor Research Institute

    Dallas, Texas, 75246, United States

  • Duke University School of Medicine

    Durham, North Carolina, 27710, United States

  • HCA Healthcare Research Institute

    Englewood, Colorado, 80113, United States

  • Hackensack Meridian Health

    Hackensack, New Jersey, 07601, United States

  • Hopital Pierre Wertheimer

    Lyon, France

  • Hopital Pitie-Salpetriere

    Paris, France

  • Hopital de La Timone

    Marseille, France

  • Hospital Duran i Reynals

    L'Hospitalet de Llobregat, Spain

  • Hospital Ramón y Cajal

    Madrid, Spain

  • Hospital Regional Universitario de Malaga Carlos Haya

    Málaga, Spain

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Spain

  • Hospital Universitario Virgen Macarena

    Seville, Spain

  • Huntsman Cancer Center

    Salt Lake City, Utah, 84112, United States

  • Institut de Cancerologie Gustave-Roussy

    Villejuif, France

  • Institut de Cancerologie de l'Ouest

    Saint-Herblain, France

  • Institut de Recherche en Cancerologie de Montpellier

    Montpellier, France

  • Istituto Clinico Humanitas

    Milan, Italy

  • Mayo Clinic

    Rochester, Minnesota, 550905, United States

  • Mayo Clinic Florida

    Jacksonville, Florida, 32224, United States

  • Milton S. Hershey Medical Center

    Hershey, Pennsylvania, 17033, United States

  • Ohio State University

    Columbus, Ohio, 43210, United States

  • Piedmont Healthcare

    Atlanta, Georgia, 30309, United States

  • Providence Health

    Portland, Oregon, 97225, United States

  • Roswell Park Cancer Center

    Buffalo, New York, 14263, United States

  • Rush University Cancer Center

    Chicago, Illinois, 60612, United States

  • Rutgers University

    Piscataway, New Jersey, 08854, United States

  • Saint John's Cancer Institute at Providence Saint John's Health Center

    Santa Monica, California, 90404, United States

  • Servizio Sanitario Regionale Emilia-Romagna - Azienda USL di Bologna - Ospedale Bellaria

    Bologna, Italy

  • Southern California Permanente Medical Group

    Los Angeles, California, 90027, United States

  • Swedish Medical Center

    Seattle, Washington, 98122, United States

  • Texas Oncology PA

    Austin, Texas, 78758, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • Tulane Cancer Center Clinic

    New Orleans, Louisiana, 70112, United States

  • UMass (ACC) - Hollings Cancer Center (HCC)

    Worcester, Massachusetts, 01655, United States

  • University Hospital Zurich

    Zurich, 8091, Switzerland

  • University of Arkansas

    Little Rock, Arkansas, 72205, United States

  • University of Califonia San Diego Moores Cancer Center

    San Diego, California, 92093, United States

  • University of California Irvine

    Orange, California, 92868, United States

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of Kentucky

    Lexington, Kentucky, 40536, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77027, United States

  • University of Wisconsin Hospital and Clinics

    Madison, Wisconsin, 53705, United States

  • nstitut Universitaire du Cancer de Toulouse-

    Toulouse, France

Conditions

Explore the condition pages connected to this study.