New hope for glioblastoma: experimental drug berubicin faces key trial

NCT ID NCT04762069

Ongoing Disease control Sponsor: CNS Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests an experimental chemotherapy drug called berubicin against a standard drug (lomustine) in 252 adults with recurrent glioblastoma, a severe brain cancer. The goal is to see if berubicin can help patients live longer after standard first-line treatment has failed. Participants are randomly assigned to receive either berubicin or lomustine, and the study tracks survival and tumor progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Berubicin (a chemotherapy drug similar to doxorubicin)
What this could lead to: If successful, berubicin could offer a new treatment option for recurrent glioblastoma, potentially extending survival for patients who have run out of standard options.
What could go wrong: This is a Phase 2 trial, so results are still early. The drug may not improve survival compared to the current standard, and chemotherapy side effects like heart toxicity are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adult glioblastoma brain cancer glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA MULTIFORME, ADULT

Contacts and locations

Locations

Atlantic Healthcare

Summit, New Jersey, 07901, United States
Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Baptist Miami

Miami, Florida, 33176, United States
Baylor Research Institute

Dallas, Texas, 75246, United States
Duke University School of Medicine

Durham, North Carolina, 27710, United States
HCA Healthcare Research Institute

Englewood, Colorado, 80113, United States
Hackensack Meridian Health

Hackensack, New Jersey, 07601, United States
Hopital Pierre Wertheimer

Lyon, France
Hopital Pitie-Salpetriere

Paris, France
Hopital de La Timone

Marseille, France
Hospital Duran i Reynals

L'Hospitalet de Llobregat, Spain
Hospital Ramón y Cajal

Madrid, Spain
Hospital Regional Universitario de Malaga Carlos Haya

Málaga, Spain
Hospital Universitari Germans Trias i Pujol

Badalona, Spain
Hospital Universitario 12 de Octubre

Madrid, Spain
Hospital Universitario Virgen Macarena

Seville, Spain
Huntsman Cancer Center

Salt Lake City, Utah, 84112, United States
Institut de Cancerologie Gustave-Roussy

Villejuif, France
Institut de Cancerologie de l'Ouest

Saint-Herblain, France
Institut de Recherche en Cancerologie de Montpellier

Montpellier, France
Istituto Clinico Humanitas

Milan, Italy
Mayo Clinic

Rochester, Minnesota, 550905, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Ohio State University

Columbus, Ohio, 43210, United States
Piedmont Healthcare

Atlanta, Georgia, 30309, United States
Providence Health

Portland, Oregon, 97225, United States
Roswell Park Cancer Center

Buffalo, New York, 14263, United States
Rush University Cancer Center

Chicago, Illinois, 60612, United States
Rutgers University

Piscataway, New Jersey, 08854, United States
Saint John's Cancer Institute at Providence Saint John's Health Center

Santa Monica, California, 90404, United States
Servizio Sanitario Regionale Emilia-Romagna - Azienda USL di Bologna - Ospedale Bellaria

Bologna, Italy
Southern California Permanente Medical Group

Los Angeles, California, 90027, United States
Swedish Medical Center

Seattle, Washington, 98122, United States
Texas Oncology PA

Austin, Texas, 78758, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
Tulane Cancer Center Clinic

New Orleans, Louisiana, 70112, United States
UMass (ACC) - Hollings Cancer Center (HCC)

Worcester, Massachusetts, 01655, United States
University Hospital Zurich

Zurich, 8091, Switzerland
University of Arkansas

Little Rock, Arkansas, 72205, United States
University of Califonia San Diego Moores Cancer Center

San Diego, California, 92093, United States
University of California Irvine

Orange, California, 92868, United States
University of California San Francisco

San Francisco, California, 94143, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Texas Health Science Center at Houston

Houston, Texas, 77027, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53705, United States
nstitut Universitaire du Cancer de Toulouse-

Toulouse, France

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