New hope for hard-to-treat melanoma: drug combo targets NRAS mutation

NCT ID NCT04835805

Ongoing Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This early-stage study tests a new drug called belvarafenib, alone or with other drugs (cobimetinib and nivolumab), in people with advanced melanoma that has a specific NRAS gene change and has stopped responding to standard immunotherapy. The main goals are to check safety and find the right dose. About 65 adults with this type of melanoma will take part.

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Conditions

The condition(s) this trial relates to.

melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA

Contacts and locations

Locations

Asan Medical Center - PPDS

Seoul, 05505, South Korea
California Pacific Medical Center Research Institute

San Francisco, California, 94115, United States
Calvary Mater Newcastle

Waratah, New South Wales, 2298, Australia
Charité - Universitätsmedizin Berlin

Berlin, 12203, Germany
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Baltimore, Maryland, 21231, United States
Klinikum Mannheim GmbH Universitätsklinikum

Mannheim, 68167, Germany
Linear Clinical Research Ltd

Nedlands, Western Australia, 6009, Australia
Memorial Sloan Kettering

New York, New York, 10021, United States
Ottawa Hospital Regional Cancer Centre

Ottawa, Ontario, K1H 8M2, Canada
Peter MacCallum Cancer Centre-East Melbourne

Melbourne, Victoria, 3000, Australia
Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
Samsung Medical Center - PPDS

Seoul, 06351, South Korea
UCSF Helen Diller Family CCC

San Francisco, California, 94158, United States
Universitatsklinikum Tubingen

Tübingen, 72076, Germany
University of Colorado Cancer Center

Aurora, Colorado, 80045, United States
Universitätsklinikum Hamburg-Eppendorf

Hamburg, 20246, Germany
Universitätsklinikum Würzburg

Würzburg, 97080, Germany
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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