New antibody therapy enters early human testing for hard-to-treat lymphomas

NCT ID NCT04594642

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 22 times

Summary

This early-stage study tests a new drug called AZD0486 in about 227 people with B-cell non-Hodgkin lymphoma, including types like diffuse large B-cell and follicular lymphoma. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goals are to check safety, find the right dose, and see if it shrinks tumors.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Research Site

    RECRUITING

    Tampa, Florida, 33612, United States

  • Research Site

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    Louisville, Kentucky, 40207, United States

  • Research Site

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    New Brunswick, New Jersey, 08901, United States

  • Research Site

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    Charlotte, North Carolina, 28204, United States

  • Research Site

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    Columbus, Ohio, 43210, United States

  • Research Site

    WITHDRAWN

    Portland, Oregon, 97239, United States

  • Research Site

    RECRUITING

    Pittsburgh, Pennsylvania, 15237, United States

  • Research Site

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    Austin, Texas, 78704, United States

  • Research Site

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    Houston, Texas, 77030, United States

  • Research Site

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    Milwaukee, Wisconsin, 53226, United States

  • Research Site

    WITHDRAWN

    Bedford Park, 5042, Australia

  • Research Site

    RECRUITING

    Heidelberg, 3084, Australia

  • Research Site

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    Hobart, 7000, Australia

  • Research Site

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    Melbourne, 3004, Australia

  • Research Site

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    Chūōku, 104-0045, Japan

  • Research Site

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    Kōtoku, 135-8550, Japan

  • Research Site

    RECRUITING

    Nagoya, 460-0001, Japan

  • Research Site

    RECRUITING

    Yamagata, 990-9585, Japan

  • Research Site

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    Seoul, 03080, South Korea

  • Research Site

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    Seoul, 05505, South Korea

  • Research Site

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    Seoul, 06351, South Korea

  • Research Site

    RECRUITING

    Seoul, 06591, South Korea

  • Research Site

    RECRUITING

    Seoul, 120-752, South Korea

  • Research Site

    RECRUITING

    Kaohsiung City, 833401, Taiwan

  • Research Site

    RECRUITING

    Kweishan, 333, Taiwan

  • Research Site

    RECRUITING

    Tainan, 704, Taiwan

  • Research Site

    RECRUITING

    Taipei, 10002, Taiwan

Conditions

Explore the condition pages connected to this study.