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Spinal surgery anesthesia showdown: which method spares the brain?

NCT ID NCT07701187

Knowledge-focused Sponsor: Bursa Yuksek Ihtisas Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study compares two ways of giving intravenous anesthesia during spinal surgery — manual controlled infusion (MCI) and target controlled infusion (TCI) — to see which one better protects thinking and memory afterward. Researchers will test patients' cognitive function using standard assessments before and after surgery. The goal is to find out whether the method of delivering anesthesia affects the risk of postoperative cognitive problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
manual controlled infusion (MCI) and target controlled infusion (TCI) of propofol and remifentanil
What this could lead to
If one technique is found to reduce cognitive decline after surgery, it could help guide anesthesia choices to protect brain function.
What could go wrong
This is a small, early-stage study focused on measuring differences, not proving a treatment. Results may show no clear advantage for either method.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

128 people

The number who actually took part.

Started

Sep 2023

Finished

Sep 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Turkish language proficiency, * age (18-65 years), * American Society of Anesthesiologists (ASA) I-III score, * elective spinal surgery. Exclusion Criteria: * \- refusal to participate * central nervous system disorders, * use of antidepressants or antipsychotic medications, * alcohol or drug use, * illiteracy.

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Conditions

The condition(s) this trial relates to.

Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative cognitive dysfunction (POCD)

Contacts and locations

Locations

  • Bursa yüksek ihtisas eğitim ve araştırma hastanesi BURSA, Bursa, Türkiye, BURSA, Bursa 16310, BURSA, Bursa

    Bursa, Bursa, 16310, Turkey (Türkiye)

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