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Which anesthesia keeps your mind sharpest after ear surgery?

NCT ID NCT07792759

Knowledge-focused Sponsor: Dr. Lutfi Kirdar Kartal Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This trial tests three anesthesia approaches during ear surgery to see which one best protects thinking and memory afterward. Adults having elective ear surgery under controlled low blood pressure will receive either desflurane, sevoflurane, or total intravenous anesthesia with remifentanil and propofol. Researchers will compare cognitive test scores before surgery and one week after, along with brain oxygen levels and blood pressure during the procedure. The goal is to identify which method carries the lowest risk of postoperative cognitive dysfunction.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Desflurane, sevoflurane, remifentanil, and propofol are the anesthetic drugs being compared for their effects on postoperative cognitive function.
What this could lead to
If one anesthesia method proves better for preserving cognitive function, it could guide safer anesthesia choices for ear surgery patients.
What could go wrong
This is a small, single-center trial, and results may not apply to all patients or surgeries. The cognitive tests are short-term, so long-term effects remain unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

69 people

The number who actually took part.

Started

Dec 2023

Finished

Jul 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 years and older * ASA physical status I-II * Scheduled for elective tympanoplasty, mastoidectomy, or tympanomastoidectomy under general anesthesia * Provided written informed consent Exclusion Criteria: * Patients with known neurological or psychiatric disorders affecting cognitive function * Pre-existing cognitive impairment * Severe hepatic or renal insufficiency * History of alcohol or substance abuse * Inability to complete cognitive function tests * Emergency surgery * Refusal to participate in the study

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Conditions

The condition(s) this trial relates to.

Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Controlled hypotension for nasal surgeries Postoperative cognitive dysfunction (POCD)

Contacts and locations

Locations

  • Kartal Dr. Lutfi Kirdar City Hospital

    Istanbul, Istanbul, 34865, Turkey (Türkiye)

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