New pill aims to stop dangerous blood pressure drops in rare brain disease

NCT ID NCT05696717

Ongoing Symptom relief Sponsor: Theravance Biopharma Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 study tests a drug called ampreloxetine for people with multiple system atrophy (MSA) who experience dizziness and fainting due to low blood pressure when standing. About 102 adults with MSA will take the drug for 20 weeks, then some will switch to placebo to see if symptoms return. The goal is to see if ampreloxetine safely improves daily activities and reduces symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ampreloxetine (oral tablet)

What this could lead to

If it works, this could provide a new treatment option to reduce dizziness and fainting in people with multiple system atrophy, making daily activities easier.

What could go wrong

This is a mid-stage trial with only 102 participants. The drug may not work better than placebo, and side effects could occur. Results may not apply to all MSA patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

multiple system atrophy primary orthostatic hypotension Shy-Drager Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MSA - MULTIPLE SYSTEM ATROPHY SYMPTOMATIC NEUROGENIC ORTHOSTATIC HYPOTENSION

Contacts and locations

Show contact details

Locations

AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno

Salerno, 84131, Italy
Aqualane Clinical Research

Naples, Florida, 34105, United States
Astra Clinic (Clinic4U)

Tallinn, 11315, Estonia
Auckland City Hospital

Grafton, Auckland, 1023, New Zealand
Autonomic Unit, National Hospital for Neurology & Neurosurgery

London, WC1N 3BG, United Kingdom
Azienda Ospedaliera Santa Maria di Terni

Terni, I-05100, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata

Rome, 00133, Italy
Barts Health

London, EC1M 6BQ, United Kingdom
Baylor College of Medicine

Houston, Texas, 77030, United States
Bispebjerg Hospital

Copenhagen, 2400-NV, Denmark
Brigham and Women's Hospital (Neuromuscular Division)

Boston, Massachusetts, 02115, United States
CNS-Campus Neurologico Senior

Torres Vedras, 2560-280, Portugal
Centre Hospitalier Universitaire de Bordeaux Health

Bordeaux, 33076, France
Centre d'Investigation Clinique Hôpital Pierre Paul Rique

Toulouse, 31059 Cedex, France
Centro de Pesquisa Clínica (CPC) do Hospital das Clínicas de Porto Alegre (HCPA)

Porto Alegre, 90035-903, Brazil
Charite Universitaetsmedizin Berlin

Berlin, 12203, Germany
Charité - Universitätsmedizin Berlin- Campus Mitte

Berlin, 10117, Germany
David Geffen School of Medicine at UCLA

Los Angeles, California, 90095, United States
Emory University

Atlanta, Georgia, 30329, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Rome, 00168, Italy
Fundació Assistencial Mutua de Terrassa

Terrassa, Barcelona, 08222, Spain
Fundación Scherbovsky

Mendoza, M5500, Argentina
Hawaii Pacific Neuroscience

Honolulu, Hawaii, 96817, United States
Hopital Caremeau

Nîmes, Occitanie, Cedex 9, France
Hospital Británico de Buenos Aires

CABA, C1280AEB, Argentina
Hospital General de Agudos Jose Maria Ramos Mejía

CABA, C1221ADC, Argentina
Hospital Germans Trias i Pujol, Department of Neurology

Barakaldo, Bizkaia, 48903, Spain
Hospital São Lucas - PUCRS

Porto Alegre, 90610-000, Brazil
Hospital Universitario Infante Sofia Paseo Europa

Madrid, 28702, Spain
Hospital Universitario de La Princesa

Madrid, 28006, Spain
Hospital de Clínicas - Universidade Federal de Minas Gerais (HC - UFMG)

Belo Horizonte, 30130-100, Brazil
INEBA Instituto Neurociencias Buenos Aires

CABA, Buenos Aires F.D., C1192AAW, Argentina
IRCCS Istituto de Scienze Neurologiche di Bologna (ISNB)

Bologna, 40139, Italy
Instituto Fleni

CABA, Buenos Aires F.D., C1428AQK, Argentina
Instituto Investigación Sanitaria Biocruces

Barakaldo, Bizkaia, 48903, Spain
Instituto de Neurologia de Curitiba S\C LTDA

Curitiba, Paraná, 81210-310, Brazil
Instytut Zdrowia dr Boczarska-Jedynak Sp. z o.o., Sp.k.

Oświęcim, 32-600, Poland
Krakowska Akademia Neurologii Sp.zo.o.

Krakow, 31-505, Poland
Massachusetts Chan Medical School

Worcester, Massachusetts, 01655, United States
Medical University of Innsbruck

Innsbruck, A-6020, Austria
Medstar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Monash Health

Clayton, Victoria, 3168, Australia
Movement Disorders Center of Arizona

Scottsdale, Arizona, 85258, United States
Movement Disorders and Autonomic Disorders Clinic; University of Utah

Salt Lake City, Utah, 84108, United States
Médico/Hospital de la Policía Federal Churruca Visca

CABA, Buenos Aires F.D., C1437JCP, Argentina
NYU Langone Health NYU Dysautonomia Center

New York, New York, 10016, United States
National Taiwan University Cancer Center

Taipei, Taiwan, 106, Taiwan
Neuro-Care Sp. z o.o. Sp. Komandytowa

Katowice, 40-749, Poland
Neurocentrum-Miwomed

Gdansk, 80-207, Poland
Neurostudies, Inc

Port Charlotte, Florida, 33952, United States
Northshore University Health System

Glenview, Illinois, 60026-1339, United States
Parkinson's Centre of Ospedale CTO

Milan, 20126, Italy
Parkinson's Disease And Movement Disorders Center of Boca Raton

Boca Raton, Florida, 33486, United States
Pia Fond. Cardinale Giovanni Panico Azienda Ospedaliera

Tricase, 73039, Italy
Praxis Dr. Oehlwein, Outpatient Clinic

Gera, Thuringia, 07551, Germany
Quest Research Institute

Farmington Hills, Michigan, 48334, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
SFM Clinical Research, LLC

Boca Raton, Florida, 33487, United States
Salford Royal Hospital

Salford, M6 8HD, United Kingdom
Santa Chiara Hospital

Trento, 38122, Italy
Semmelweis Egyetem

Budapest, 1085, Hungary
Stanford Neuroscience Health Center

Palo Alto, California, 94304, United States
Tartu University Hospital

Tartu, 30029, Estonia
The Alfred Hospital

Melbourne, Victoria, 3168, Australia
The Neurological Institute at Columbia University Medical Center

New York, New York, 10032, United States
The Parkinson's and Movement Disorder Institute

Fountain Valley, California, 92708, United States
Theravance Biopharma Investigative Site

Parkville, Victoria, 3050, Australia
Theravance Biopharma Investigative Site

Tel Aviv, 64239, Israel
Theravance Biopharma Investigative Site

Christchurch, 8011, New Zealand
UC San Diego Movement Disorder Center

La Jolla, California, 92037, United States
Universitatsklinikum Tulln

Tulln, Austria
University Hospitals Birmingham NHS Foundation Trust

Birmingham, B15 2GW, United Kingdom
University of Belgrade Neurology Clinic

Belgrade, 11000, Serbia
University of Calgary - Health Sciences Centre

Calgary, Alberta, T2N 4Z6, Canada
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Kansas Medical Center Research Institute, Inc.

Kansas City, Kansas, 66160, United States
University of South Florida Ataxia Research Center

Tampa, Florida, 33612, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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