New targeted therapy ALX2004 enters first human trials for tough cancers

NCT ID NCT07085091

Recruiting now Disease control Sponsor: ALX Oncology Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 15, 2026 · Updated 39 times

Summary

This early-phase study tests a new drug called ALX2004 in about 170 people with advanced or metastatic solid tumors (lung, head and neck, colorectal, or esophageal cancer) that have not responded to standard treatments. ALX2004 is an antibody-drug conjugate designed to deliver a cancer-killing agent directly to cells with EGFR, a common protein on tumor surfaces. The main goals are to find a safe dose and to see if the drug can shrink tumors.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ESOPHAGEAL SQUAMOUS CELL CARCINOMA (ESCC) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

ALX Center 1
RECRUITING

Spokane, Washington, 99208, United States
ALX Center 2
RECRUITING

Fairfax, Virginia, 22031, United States
ALX Center 3
RECRUITING

Grand Rapids, Michigan, 49546, United States
ALX Center 4
RECRUITING

West Valley City, Utah, 84119, United States
ALX Center 5
RECRUITING

Houston, Texas, 77030, United States
ALX Center 6
RECRUITING

Portland, Oregon, 97213, United States
ALX Center 7
RECRUITING

Tampa, Florida, 33612, United States
ALX Center 8
RECRUITING

Farmington Hills, Michigan, 48334, United States

Conditions

Explore the condition pages connected to this study.

COLO-RECTAL CANCER COLO-RECTAL CANCER CRC (COLORECTAL CANCER) ESCC ESCC ESOPHAGEAL SQUAMOUS CELL CARCINOMA (ESCC) HEAD AND NECK CANCER HNSCC NSCLC (ADVANCED NON-SMALL CELL LUNG CANCER)