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Aloe vera mouthwash tested against chemotherapy mouth sores

NCT ID NCT07809984

Prevention Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers are studying whether aloe vera mouthwash can prevent or reduce the severity of oral mucositis, a painful mouth sore that often affects people receiving chemotherapy for acute leukemia. The trial compares aloe vera mouthwash plus usual care against usual care alone in about 206 adults. Participants in the aloe vera group rinse with the mouthwash four times a day for 28 days and answer questions about their oral health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
aloe vera mouthwash
What this could lead to
If it works, aloe vera mouthwash could offer a low-cost, easy-to-use way to prevent or ease painful mouth sores during leukemia chemotherapy.
What could go wrong
This is a small, non-randomized study, so results may not prove cause and effect. Aloe vera may not outperform usual care, and some people could have allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 206 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Medical diagnosis of acute leukemia and receiving high or low intensity chemotherapy * English speaking/reading (without an interpreter) * Access to a personal email address to support study participation Exclusion Criteria: * Patients with preexisting mucositis. * Allergy to Aloe Vera * Transplant patients * Cognitively impaired or have a psychiatric condition that would prevent ability to provide informed consent * Pregnant women * Patients with an active eating disorder * Patients receiving end of life/hospice care

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Conditions

The condition(s) this trial relates to.

acute leukemia acute lymphoblastic leukemia acute myeloid leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma stomatitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute leukemia Acute lymphoblastic leukemia Acute myeloid leukemia Oral mucositis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Advocate Christ Medical Center

    Oak Lawn, Illinois, 60453, United States

  • Advocate Lutheran General

    Park Ridge, Illinois, 60068, United States

  • Aurora St. Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

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