Can switching meds help smokers who slip? new study aims to find out
NCT ID NCT06118502
First seen Mar 09, 2026 · Last updated Jun 22, 2026 · Updated 17 times
Summary
This study tests whether changing treatments after an early relapse helps smokers quit. 544 smokers who want to quit will try nicotine patches, lozenges, varenicline, or e-cigarettes. If they slip in the first few weeks, they may switch to a different option. All visits are remote, and treatments are free for 12 weeks.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nicotine replacement therapy (patches/lozenges), varenicline, or e-cigarettes
What this could lead to
If successful, this could show that switching treatments after an early relapse helps more smokers quit long-term.
What could go wrong
This is a behavioral study without a placebo control, so results may not prove which strategy works best. E-cigarettes carry their own health risks.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.