New pill shows promise in taming Hard-to-Treat blood cancers

NCT ID NCT02029443

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests a new oral drug called acalabrutinib (ACP-196) in people with chronic lymphocytic leukemia (CLL) or related blood cancers that have not responded to at least two prior treatments. The goal is to see if the drug is safe and can shrink or control the cancer. About 306 adults took part, and the drug works by blocking a protein that helps cancer cells grow.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary โ€” we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia prolymphocytic leukemia Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Research Site

    Boston, Massachusetts, 2215, United States

  • Research Site

    New Hyde Park, New York, 11042, United States

  • Research Site

    New York, New York, 10021, United States

  • Research Site

    Columbus, Ohio, 43210, United States

  • Research Site

    Fort Worth, Texas, 76104, United States

  • Research Site

    Salt Lake City, Utah, 84112, United States

  • Research Site

    Seattle, Washington, 98122, United States

  • Research Site

    Tacoma, Washington, 98405, United States

  • Research Site

    Milan, 20132, Italy

  • Research Site

    Leeds, LS9 7TF, United Kingdom

  • Research Site

    London, SE5 9RS, United Kingdom

  • Research Site

    Oxford, OX3 7LE, United Kingdom